Table 3.
Synopsis of the Crosstalk between miRNA and lncRNA for EMT
| Cancer | Pre-clinical | Mechanism | miRNA | lncRNA | Therapeutic intervention for tumor regression | Cellular Signaling | Ref. |
|---|---|---|---|---|---|---|---|
| CRC | in vitro | Down regulation | miR-138 and miR-200a | H19 | NA | E-cadherin | [84] |
| Breast cancer | in vivo | Sponging | miR-1 | MALAT-1 | Knockdown of MALAT1 inhibited breast cancer | NA | [85] |
| CC | in vitro | Sponging | miR-361 | NEAT1 | PI3K/AKT | [86] | |
| CRC | in vivo | Sponging | MiR-489 | Cardiac hypertrophy-related factor (CHRF) | CHRF knockdown increased the expression of miR-489 and suppressed CRC | TWIST1/EMT | [87] |
| CRC | in vivo | Sponging | miR-215 | UICLM | knockdown of UICLM inhibited CRC | NA | [88] |
| Lung cancer | in vivo | NA | MiR-193a-3p, miR-210-3p, and miR-5100 | DNMT1 | NA | STAT3 | [89] |
| Pancreatic ductal adenocarcinoma cells | in vivo | NA | EV-miR-200 | EV-lncRNA-Sox2ot | NA | NA | [90] |
| HCC | in vivo | Sponging | miRlet-7 | H19 | NA | NA | [91] |
| Pancreatic cancer | in vivo | Sponging | miR181-b | DLX6-AS1 |
knockdown of DLX6-AS1 inhibiting PC |
E-cadherin upregulated and downregulated MMP2 | [92] |
| Bladder cancer | in vitro | Sponging | miR-129-5p | LncARSR | knockdown of LncARSR inhibited bladder cancer | STAT3; SOX4 | [93] |
| Breast cancer | in vivo | Sponging | miR-223 | DLX6-AS1 | DLX6-AS1 silencing inhibited breast cancer | Wnt beta -catenin | [94] |
| Glioma | in vitro | NA | miR-1 and miR-203a | UCA1 | knockdown of UCA1 inhibited glioma |
downregulation of slug; TGF-beta pathway |
[95] |