Table 4.
Synopsis of the Crosstalk between miRNA and lncRNA for Vascular mimicry
| Cancer | Pre-clinical | Mechanism | miRNA | lncRNA | Cellular Changes | Therapeutic intervention for tumor regression | Cellular Signaling | Ref. |
|---|---|---|---|---|---|---|---|---|
| Glioma | in vivo | Sponging | miR-373 | HOXA-AS2 | Cellular proliferation |
knockdown of HOXA-AS2 inhibited glioma |
PIP3 and EGFR | [103] |
| Glioma, Breast cancer | in vivo | Negative regulation | miR-539-5p | TWIST1 | Migration, invasion |
knockdown of TWIST1 inhibited glioma |
MMP-2 and MMP-14 | [104, 105] |
| Hepatocellular carcinoma | in vitro | Sponging | miR-31-3p, miR-30e-5p, miR-519c-5p, miR-520c-5p, miR-29b-1-5p, and miR-92a-1-5p | n339260 | Stemlike features and VM development; Cellular proliferation | Knockdown of LINC00339 inhibited glioma cell | MMP-2, MMP-9, and MMP-14 | [106] |
| Lung cancer | in vitro | Sponging | miR-145-5p | MALAT1 | VM causing metastasis |
knockdown of molecular effector molecule Erβ inhibited lungs cancer |
NEDD9 | [107] |