Table 7.
Synopsis of the Crosstalk between miRNA and lncRNA influencing invasion
| Cancer | Pre-clinical | Mechanism | miRNA | lncRNA | Therapeutic intervention for tumor regression | Cellular Signaling | Ref. |
|---|---|---|---|---|---|---|---|
| Renal cell carcinoma | in vitro | Sponging | miR-129 | UCA1 | CA1 knockdown in RCC cells | NA | [170] |
| Gastrointestinal cancer | in vitro | Sponging | miR-203 and miR-7-5p | UCA1 | Knockdown of UCA1 inhibited GIC | AKT/GSK-3β | [171, 172] |
| Bladder Cancer | in vitro | Sponging | miR-196a-5p | UCA1 | Knockdown of UCA1 | NA | [173, 174] |
| Bladder cancer | in vitro | NA | miR-195 | UCA1 | knockdown of UCA1 inhibited bladder cancer | MiR-195/ARL2 | [175–177] |
| Melanoma | in vitro | NA | anti-miR-185-5p | UCA1 | NA | NA | [178, 179] |
| Melanoma | in vitro | NA | FOXM1 (miR-507) | UCA1 | NA | NA | [180, 181] |
| Osteosarcoma | in vitro | NA | miR-182 | TIMP2 | NA | NA | [162] |
| Breast cancer | in vitro | Sponging | miR-122-5p | UCA1 | NA | FGFR1 and ERK | [182] |
| Osteosarcoma | in vitro | NA | miR-129-5p | DLX6-AS1 and DLK1 | DLX6-AS1 knockdown decreased tumor sphere number and size in MG63 and U2OS cells | Wnt-beta pathway | [183] |
| Urothelial carcinoma | in vitro | Negative Regulation | miR-204e5p | UCA1 | UCA1 knockdown and miR-204-5p overexpression induced downregulation target genes in HCT116 cells. | UCA1/miR-204-5p ceRNA | [113] |
| CRC | in vitro | miR-203a-3p, miR-545 and miR-218 | HOTAIR | Both HOTAIR knockdown and miR-203a-3p overexpression inhibited CRC | Wnt- b-catenin, EGFR | [114, 115] | |
| Colon cancer, Gastric adenocarcinoma | in vitro | NA | miR-34a | lnc34a | NA | PI3K/Akt/mTOR | [36, 184, 185] |
| CRC | in vitro | Sponging | miR-369e3p | OIP5-AS1 | NA | NA | [119] |
| CRC | in vitro | Sponging | miR-29a | LIFRAS1 | miR-29a significantly inhibited CRC | Wnt/β-catenin | [120] |
| Lung cancer | in vitro | Sponging | miR-142 | DLX6-AS1 | knockdown of lncRNA and up-regulation of miR-142inhibited LC | NA | [122, 123] |
| Lung cancer | in vitro | miR-193a | UCA1 | knocking down miR-193a-3p | PTEN/PI3K | [124] | |
| Bladder and lung cancers | in vitro | NA | miR-144 | UCA1 | Knockdown of lncRNA UCA1 inhibited lung cancer | NA | [125, 126] |
| Lung cancer | in vitro | NA | miR-143 | UCA1 | NA | NA | [127] |
| Hepatocellular carcinoma | in vitro | Sponging | miR-203a and miR-424-5p | DLX6-AS1 | Knockdown DLX6-AS1 inhibited HCC | EGFR/PI3K/AKT | [128, 129] |
| Pancreatic cancer | in vitro | NA | miR-181b | DLX6-AS1 | NA | NA | [132] |
| Pancreatic cancer | in vitro | Sponging | miR-497-1 | DLX6-AS1 | knockdown of DLX6-AS1 inhibited PC | FZD4/FZD6/Wnt/β-catenin | [133] |
| Pancreatic cancer | in vitro | Sponging | miR-96 and miR-135a | UCA1 | knockdown of UCA1 inhibited PC | NA | [134, 186] |
| Gastric cancer | in vitro | NA | miR-204-5p | DLX6-AS1 | Knockdown of DLX6-AS1 inhibited GC. | GSK3-β catenin; upregulated E-cadherin protein; downregulated N-cadherin and vimentin protein | [145–147] |
| Gastric cancer | in vitro | Sponging | miR-331-3p | HOTAIR | knockdown of HOTAIR inhibited GC | NA | [187] |
| Gastric cancer | in vitro | miR-675 | H19 | H19 knockdown inhibited GC | NA | [135, 136] | |
| Gastric cancer | in vitro | NA | miR-211-3p | GAPLINC | Knockdown of GAPLINC | NA | [137, 138, 150] |
| CC | in vitro | Sponging | miR-199a | DLX6-As1 | Knockdown of DLX6AS1 inhibited CC | NA | [188] |
| CC | in vitro | Sponging | miR-143-3p | OIP5-AS1 | NA | OIP5-AS1/miR-143-3p-ROCK1 | [144] |
| CC | in vitro | Sponging | miR-21 | GAS5 | knockdown of GAS5 inhibited CC | NA | [189] |