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Acute inflammation increases bone FGF23 production. (A) Fgf23 promoter activity in MC3T3-E1 osteoblasts in response to escalating doses of IL-1β and calcium used as positive control. Serum (B) cFGF23, (C) iFGF23, (D) i/cFGF23, and (E) bone Fgf23 mRNA expression in 6-week-old WT mice, 6 hours after administration of a single dose of IL-1β. n ≥ 3 per group, P < .05 vs (a) 0 (Ctr), (b) 5, (c) 10 ng/mL, and (d) 50 ng/g IL-1β.
