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. 2023 Jul 19;14:4361. doi: 10.1038/s41467-023-40045-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A A representative 3D complex structure (PDB 6CMO) with GPCR and G-protein SSE labels; B SSE contact network for G_s complexes: GPCR and G-protein nodes are colored in green and cyan, respectively. Node diameter is proportional to the total number of contacts mediated by that SSE. Edge thickness is proportional to the number of contacts between connected SSEs and coloring (darker red) is directly proportional to contact conservation; C SSE contact network for G_i/o complexes. Network characteristics as in 2 A; D GPCR SSE network node degree distribution for G_s and G_i/o networks; E G-protein SSE network node degree distribution for G_s and G_i/o networks; F GPCR SSE network betweenness centrality distribution. Source data are provided as a Source Data file.