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. 2023 Jul 19;14:4361. doi: 10.1038/s41467-023-40045-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A fractions of experimental coupling groups of the receptors clustered identified through CF clustering; B violin plot showing the distribution of the LOR statistics for GPCR-G-protein contacts. Dashed lines indicate the median value; C G_i/o log-odds ratio statistics represented with a color scale ranging from blue (negative LOR) to red (positive LOR) using B-factor annotations on a representative structure (PDB ID: 7VL9): receptor (top, chain R), G-protein (bottom, chain A) along with distribution of the LOR statistics for GPCR (top) and G-protein (bottom) contact positions. Dashed lines in the violin plots indicate the median value; D G_s complexes contact frequency heatmaps: columns are GPCR positions in GPCRdb numbers, and rows are G-protein positions in CGN numbers. Only contacts with frequency > 20% (over the number of unique complexes) are considered; E Gi/o complexes contact frequency heatmaps: representation features are as in 4D; F structural comparison of G_s complexes mediated by a class A (HTR6; cyan; PDB: 7XTB) and class B representative (ADCYAP1R1; light green; PDB 6P9Y) and zoomed view of the contacts mediated by GPCR positions 6.39, 6.40 and 5.69, respectively with G-protein positions H5.23, H5.24, H5.25, H5.26; G zoomed view of the contacts mediated by GPCR position 3.49 in a representative G_i/o complex (CCKAR; PDB 7EZH) and distances between closest G-protein amino acids to E138 3.49 in the G_s complex of the same receptor (PDB: 7MBX). Source data are provided as a Source Data file.