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. 2023 Jul 19;13:11648. doi: 10.1038/s41598-023-38340-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression levels of differentially expressed p53 target genes in 2 datasets. Box and whisker plots represent median and inter-quartile range (P25–P75). mRNA expression of the (a) 7-gene signature based on the GSE138518 dataset, (b) 6-gene signature according to the GSE155489 study. R package (version 4.1.2) limma, using an Empirical Bayes method, Benjamini–Hochberg adjustment for correction and control of the FDR (False Discovery Rate) across significant genes, and t-test, was applied to identify differentially expressed genes. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.