Table 1.
The functional analyses of deregulated genes targeted by p53 to identify the statistically significant GO terms.
| Category/GO identifier | Terms | p Adj value | Overlapped genes |
|---|---|---|---|
|
GO_BPa GO:0000079 |
Regulation of cyclin-dependent protein serine/threonine kinase activity | 4.00E-13 |
CCNB2;CCND3;CCNB1;CCND2;CCND1; CCNE2;GADD45A;CCNG1;PTEN |
| GO:1904029 | Regulation of cyclin-dependent protein kinase activity | 8.04E-13 |
CCNB2;CCND3;CCNB1;CCND2;CCND1 ;CCNE2;GADD45A;CCNG1 |
| GO:0071900 | Regulation of protein serine/threonine kinase activity | 2.17E-10 |
CCNB2;CCND3;CCNB1;CCND2;CCND1 ;CCNE2;GADD45A;CCNG1 |
| GO:0031571 | Mitotic G1 DNA damage checkpoint signaling | 2.80E-10 | CCNB1;CCND1;GADD45A;CDK1;MDM2;BAX |
| GO:0044772 | Mitotic cell cycle phase transition | 4.36E-10 |
STEAP3;CCND2;CASP8;GADD45A;IGFBP3;CDK1; PMAIP1;FAS;BAX;BID;THBS1;GADD45G |
| GO:0042981 | Regulation of apoptotic process | 4.05E-09 | CCNB1;GADD45A;CDK1;MDM2;BAX |
|
GO:0006977 GO:1901992 GO:2000142 GO:0045787 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Positive regulation of mitotic cell cycle phase transition Regulation of DNA-templated transcription, initiation Positive regulation of cell cycle |
7.50E-09 8.16E-09 9.93E-09 1.32E-08 |
CCNB1;GADD45A;CDK1;MDM2;BAX CCND3;CCNB1;CCND2;CCND1;CDK4;CDK1 CCNB1;CCND1;CDK4;PTEN;CDK1;BAX CCND3;CCNB1;CCND2;CCND1;CDK4;MDM2 |
|
GO_CCb GO:0000307 |
Cyclin-dependent protein kinase holoenzyme complex | 1.40E-18 |
CCNB2;CCND3;CCNB1;CCND2;CCND1; CCNE2;CDK4;CCNG1;CDK1 |
| GO:1902554 | Serine/threonine protein kinase complex | 6.07E-18 | CCNB2;CCND3;CCNB1;CCND2;CCND1;CCNE2;CDK4;CCNG1;CDK1 |
| GO:0031265 | CD95 death-inducing signaling complex | 1.82E-04 | CASP8;FAS |
|
GO:0005741 GO:0005634 |
Mitochondrial outer membrane Nucleus |
1.82E-04 1.82E-04 |
CASP8;PMAIP1;BAX;BID GADD45A;IGFBP3;PTEN;GADD45G;CCNB2;CCND3 ;CCNB1;CCND2;CCND1;CCNE2;CDK4;CCNG1;CDK1 ;MDM2;PMAIP1;BAX |
|
GO:0031968 GO:0031264 GO:0043231 GO_MFc GO:0016538 |
Organelle outer membrane Death-inducing signaling complex Intracellular membrane-bounded organelle Cyclin-dependent protein serine/threonine kinase regulator activity |
2.42E-04 2.91E-04 7.77E-04 6.64E-12 |
CASP8;PMAIP1;BAX;BID CASP8;FAS GADD45A;IGFBP3;PTEN;GADD45G;CCNB2;CCND3 ;CCNB1;CCND2;CCND1;CCNE2;CDK4;CCNG1; CDK1;MDM2;PMAIP1;BAX CCNB2;CCND3;CCNB1;CCND2;CCND1; CCNE2;CCNG1 |
|
GO:0019887 GO:0019900 GO:0008353 GO:0097472 GO:0004693 |
Protein kinase regulator activity Kinase binding RNA polymerase II CTD heptapeptide repeat kinase activity Cyclin-dependent protein kinase activity Cyclin-dependent protein serine/threonine kinase activity |
1.15E-09 5.19E-04 0.001835336 0.004649277 0.004649277 |
CCNB2;CCND3;CCNB1;CCND2; CCND1;CCNE2;CCNG1 CCND3;CCNB1;CCND2;CCND1; GADD45A;FAS CDK4;CDK1 CDK4;CDK1 CDK4;CDK1 |
a: GO_BP, Gene Ontology Biological Process (p < 0.001).
b: GO_CC, Gene Ontology Cellular Component (p < 0.01).
c: GO_MF, Gene Ontology Molecular Function (p < 0.01).