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. 2023 Jul 19;14:4323. doi: 10.1038/s41467-023-40064-9

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Safety margin (AC₅₀ vs. therapeutic free plasma concentration) of drug-assay pairs by type: on-target activities, i.e., the drug’s mechanism of action (MOA) (blue), off-target activities known in literature-based resources (orange), unpublished off-target activities (yellow). Distributions are shown as violin plots, with the first and third quartiles denoted with lines. b Cumulative distribution of physiological activities (target activities with safety margin <10) for 894 drugs, sorted by increasing overall promiscuity (% of results with AC₅₀ < 10 µM).