Table 3.
Cox regression analysis of clinicopathologic factors for progression-free survival in women with early-stage UCS: univariate and multivariate analysis
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Maximum tumor diameter | – | – | ||
| < 5 cm | 1 | |||
| ≥ 5 cm | 1.407 (0.768–2.580) | 0.269 | ||
| Depth of myometrial invasion | ||||
| < 50% | 1 | 1 | ||
| ≥ 50% | 2.811 (1.507–5.244) | 0.001 | 1.288 (0.282–5.886) | 0.744 |
| LVSI | – | – | ||
| Absent | 1 | |||
| Present | 1.635 (0.905–2.953) | 0.103 | ||
| Histologic subtype of epithelial component | ||||
| Endometrioid G1-2 | 1 | 1 | ||
| Endometrioid G3 | 1.563 (0.694–3.521) | 0.281 | 1.226 (0.540–2.784) | 0.627 |
| Other (serous/clear cell/undifferentiated) | 2.405 (1.009–5.733) | 0.048 | 1.746 (0.693–4.400) | 0.237 |
| Histologic subtype of sarcomatous component | ||||
| Homologous | 1 | 1 | ||
| Heterologous | 3.220 (1.771–5.857) | < 0.001 | 2.362 (1.207–4.623) | 0.012 |
| FIGO stage | ||||
| IA | 1 | 1 | ||
| IB | 2.437 (1.183–5.020) | 0.016 | 1.975 (0.363–10.752) | 0.431 |
| II | 4.431 (2.114–9.289) | < 0.001 | 3.137 (0.660–14.912) | 0.151 |
Bold values: p value < 0.05