Table 4.
Cox regression analysis of clinicopathologic factors for overall survival in women with early-stage UCS: univariate and multivariate analysis
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Maximum tumor diameter | – | – | ||
| < 5 cm | 1 | |||
| ≥ 5 cm | 1.688 (0.847–3.364) | 0.137 | ||
| Depth of invasion | ||||
| < 50% | 1 | 1 | ||
| ≥ 50% | 2.888 (1.447–5.762) | 0.003 | 2.132 (0.276–16.482) | 0.468 |
| LVSI | - | - | ||
| Absent | 1 | |||
| Present | 1.427 (0.746–2.730) | 0.282 | ||
| Histologic subtype of epithelial component | – | – | ||
| Endometrioid G1-G2 | 1 | |||
| Endometrioid G3 | 1.468 (0.578–3.725) | 0.419 | ||
| Other (serous/clear cell/undifferentiated) | 1.934 (0.728–5.141) | 0.186 | ||
| Histologic subtype of sarcomatous component | ||||
| Homologus | 1 | 1 | ||
| Heterologus | 2.484 (1.335–4.621) | 0.004 | 1.950 (1.032–3.684) | 0.040 |
| FIGO Stage | ||||
| IA | 1 | 1 | ||
| IB | 2.460 (1.122–5.394) | 0.025 | 1.053 (0.118–9.415) | 0.963 |
| II | 3.709 (1.659–8.291) | 0.001 | 1.543 (0.195–12.199) | 0.681 |
Bold values: p value < 0.05
UCS uterine carcinosarcoma, HR hazard ration, CI confidence interval, LVSI lymph-vascular space invasion, FIGO International Federation of Gynecology and Obstetrics