Table 2.

Treatment characteristics and treatment response in Cohort A and Cohort B treated with standard therapy (oral steroids) and ozone therapy.

Patient characteristics	Cohort A (Steroid therapy only) (n = 23)	Cohort B (Steroid therapy and ozone therapy) (n = 24)	Value of p
Median follow-up time (months)	12 (range, 12–35)	13 (range, 12–23)	0.447*
Number of ozone applications	NA	16 (range, 10–25)
Median week of steroid use	26 (range, 16–36)	12 (range, 8–32)	0.001
Median maximum methyl prednisolone dose per day	16 mg (range, 8–32)	16 mg (range, 8–32)	0.650
Response to four-month therapy after diagnosis			0.005
Complete response rate	0% (0/23)	37.5% (9/24)
Partial response (>50% disappearance of lesions)	65.2% (15/23)	54.2% (13/24)
Minimal response (<50% disappearance of lesions)	30.4% (7/23)	8.3% (2/24)
No response/progression	4.3% (1/23)	0% (0/24)
Complete response rate	0% (0/23)	37.5% (9/24)	0.002
One-year breast recurrence rate	70% (16/23)	21% (5/24)	0.001
Two-year breast recurrence rate	73.9% (17/23)	29.2% (7/24)	0.003

*Mann–Whitney U-test was used. N.A. = not applicable.