Table 1.
Type of CNMs | Nanocarrier | Active constituent | Application | Inference | Ref. |
---|---|---|---|---|---|
Fullerenes | Nanodiamond composite | - | PDT | Enhanced survival time, cell apoptosis, and tumor shrinkage with no toxicity | Lee et al 97 |
NPs | Antenna | PTT and PDT | Tumor growth inhibition via synergistic PTT and PDT | Shi et al 98 | |
Micelles | DTX | Chemo-PDT | Increased antitumor effect with radiation as well as synergistic chemo-PDT | Guo et al 75 | |
CNTs | Nanotubes | Annexin A5 | PTT | Tumor metastasis suppression with no toxicity | McKernan et al 83 |
Nanotubes | Glycated chitosan | PTT | Highly efficient therapy for primary tumors | Li et al 99 | |
Nanotubes | Spermine | PDT | Better photophysical properties as well as PDT shows lower cell viability | Ogbodu et al 100 | |
CDs | Nanogel | Poly(N-isopropylacrylamide) | PTT and PDT | Efficient agent delivery with high therapeutic efficacy and lower adverse effects | Zhao et al 101 |
NPs | DOX | Chemo-phototherapy | Delivery of DOX to tumor cells with radiation as well as synergistic chemo-phototherapy | Zhang et al 102 | |
CNHs | - | IR808 | PTT and PDT | Cancer cells ablation and enzyme-responsive theranostic agents | Gao et al 45 |
Zinc phthalocyanine | Photohyperthermia and PDT | Disappearance of tumors with laser radiation | Zhang et al 46 | ||
GO | - | Folic acid, Ce6 | PTT and PDT | Excellent photothermal and photodynamic properties | Guo et al 103 |
Nanocomposites | (4-Carboxybutyl)triphenylphosphonium bromide (TPP), ICG | PTT and PDT | Tumor progression inhibition with no toxicity as well as a higher anticancer effect | Zeng et al 104 | |
Nanoflakes | DOX, folic acid | Chemo-PTT | Cost-efficient approach with excellent photothermal efficacy as well as targeted action | Mauro et al 105 | |
Nanographene | NPs | PEG | PTT | Enhanced biocompatibility as well as physiochemical properties | Georgieva et al 106 |
Nanoplatform | Hemin, Ce6 | PDT | High capability to suppress the tumor along with ROS production | Sahu et al 107 | |
Nanoplatform | Methylene blue | PTT and PDT | More toxic to breast cancer cells as well as prevent metastasis | Dos Santos et al 108 | |
Nanocomposite | PEG | PTT and PDT | Utilized as a theranostic medicine for cancer treatment | Kalluru et al 109 | |
rGO | Nanocomposite | DOX | Chemo-PTT | Enhanced apoptosis of cells and decreased proliferation of cells | Dash et al 110 |
Nanocomposite | Iron oxide | PTT | Lesser cell viability in cancer cells and antiapoptotic protein overexpression | Barrera et al 111 | |
Nanoplatform | IR820, DOX | Chemo-PTT and PDT | Effective therapeutic effect with low DOX and high IR820 as well as higher cytotoxic effect with NIR | Zaharie-Butucel et al 112 | |
GQDs | Liposomes | ICG | PTT | Excellent photothermal properties as well as reduced cell viability of cancer cells | Liu et al 113 |
Nanocomplexes | DOX, siRNA | Chemo-photothermal gene therapy | Good therapeutic efficacy and low toxicity as well as controlled release of drugs and siRNA | Yang et al 114 | |
QDs | Boron | PTT and PA agent | Tumor growth inhibition as well as outstanding PA agents | Guo et al 115 | |
- | Bismuth sulfide | PTT and PDT | Utilized as a photoactive agent with outstanding biocompatibility | Yang et al 116 | |
Nanomedicine | Copper(I) iodide, zinc stearate | PTT and PDT | Used as theranostic nanomedicine with good therapeutic efficiency as well as imaging potential | Lv et al 117 |
Abbreviations: CDs, carbon dots; Ce6, chlorin e6; CNHs, carbon nanohorns; CNMs, carbonaceous nanomaterials; CNTs, carbon nanotubes; DOX, doxorubicin; DTX, docetaxel; GO, graphene oxide; GQDs, graphene quantum dots; ICG, indocyanine green; NPs, nanoparticles; PA, photoacoustic; PDT, photodynamic therapy; PEG, polyethylene glycol; PTT, photothermal therapy; QDs, quantum dots; rGO, reduced graphene oxide; ROS, reactive oxygen species.