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(A) Hydrophobicity analysis graph of Hol187, according to the algorithm of Kyte and Doolittle (20). Hydrophobic regions are in the area above zero, and the central hydrophilic domain is indicated in the area below zero. The mean hydrophobicity index is 0.97, which strongly indicates a membrane location. (B) Simplified schematic representation of the predicted secondary structure of Hol187 (antiparallel helices). Charged amino acids are indicated with plus and minus signs, respectively.
