Table 4.
Predictors of hospitalisation and death (in the adult population) in univariable logistic regression models
| Outcome | Children | Adults | |
| Severe disease | Death | Hospitalisation | |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Pulmonary arterial hypertension | 5.89 (2.30 to 15.07) p<0.001 | 3.74 (1.80 to 7.79) p<0.001 | |
| Body mass index >30 kg/m2 | 0.48 (0.11 to 2.21) p=0.35 | 1.93 (0.95 to 3.94) p=0.07 | |
| Body mass index | 0.94 (0.83 to 1.06) p=0.29 | 1.05 (0.98 to 1.12) p=0.17 | 1.07 (1.02 to 1.13) p=0.01 |
| z-score weight | 0.91 (0.77 to 1.09) p=0.31 | ||
| Univentricular circulation | 1.03 (0.35 to 3.01) p=0.95 | 0.41 (0.09 to 1.79) p=0.23 | 0.57 (0.26 to 1.25) p=0.16 |
| Prior use of anticoagulation | 0.99 (0.41 to 2.40) p=0.99 | 1.22 (0.40 to 3.72) p=0.73 | 1.46 (0.72 to2.98) p=0.30 |
| At least one comorbidity | 1.54 (0.70 to 3.39) p=0.28 | 2.13 (0.86 to 5.25) p=0.10 | 6.85 (3.39 to13.87) p<0.001 |
| Genetic disease | 0.72 (0.30 to 1.74) p=0.47 | 4.89 (1.76 to 13.64) p=0.002 | 7.78 (3.18 to 19.04) p<0.001 |
| Baseline oxygen saturations <90% | 1.62 (0.61 to 4.25) p=0.33 | 2.51 (0.98 to 6.46) p=0.06 | 2.24 (1.15 to 4.39) p<0.001 |
| Baseline oxygen saturations | 1.19 (0.72 to 1.72) p=0.61 | 1.97 (1.29 to 2.99) p=0.002 | 1.51 (1.11 to 2.05) p=0.008 |
| Female sex | 2.32 (1.10 to 4.88) p=0.03 | 0.75 (0.32 to 1.76) p=0.50 | 1.07 (0.62 to 1.87) p=0.81 |
| Age (years) | 0.83 (0.75 to 0.91) p<0.001 | 1.05 (1.02 to 1.08) p<0.001 | 1.04 (1.02 to 1.06) p<0.001 |
| Age >50 years | 3.79 (1.48 to 9.72) p=0.006 | 3.56 (1.73 to 7.33) p=0.001 | |
| Age≤1 year | 6.00 (2.56 to 14.04) p<0.001 | ||
| Ethnicity (reference: white) | |||
| Asian | 1.79 (0.67 to 4.76) p=0.25 | 0.98 (0.20 to 4.76) p=0.98 | 1.01 (0.35 to 2.91) p=0.98 |
| Black | 3.90 (0.66 to 23.15) p=0.13 | 1.96 (0.20 to 18.91) p=0.56 | 1.35 (0.22 to 8.43) p=0.75 |
| Mixed or other | 0.61 (0.24 to 1.52) p=0.29 | 0.54 (0.22 to 1.36) p=0.19 | 0.56 (0.33 to 0.73) p=0.05 |
| Asymptomatic | 0.28 (0.18 to 0.63) p=0.002 | 0.63 (0.08 to 5.08) p=0.665 | 0.84 (0.30 to 2.39) p=0.745 |
| Respiratory distress | 24.04 (6.58 to 87.85) p<0.001 | 1.31 (0.52 to 3.31) p=0.57 | 1.57 (0.86 to 2.88) p=0.15 |
‘Severe disease’ defined as an episode requiring hospital admission, including emergency department assessment and ‘hospice at home’ management).