Table. Cohort Incidence Rate and Cumulative Incidence of PCC Diagnosis.
| Characteristics | During follow-up, No. | Occurrence of PCC | ||
|---|---|---|---|---|
| PCC | No PCC | Incidence rate per 100 person-years (95% CI) | Cumulative incidence, % (95% CI) | |
| Overall | 326 | 162 057 | 0.15 (0.14-0.17) | 0.20 (0.18-0.22) |
| Sex | ||||
| Boys | 128 (39.2) | 81 661 (50.4) | 0.12 (0.10-0.14) | 0.16 (0.13-0.19) |
| Girls | 198 (60.7) | 80 396 (49.6) | 0.19 (0.16-0.22) | 0.25 (0.21-0.28) |
| Age groupa | ||||
| 6-11 y | 113 (34.7) | 83 495 (51.5) | 0.11 (0.09-0.14) | 0.14 (0.11-0.16) |
| 12-17 y | 211 (64.7) | 78 564 (48.4) | 0.19 (0.17-0.22) | 0.27 (0.23-0.31) |
| Comorbidities | ||||
| Anyb | 300 (92.0) | 142 894 (88.2) | 0.16 (0.14-0.18) | 0.21 (0.19-0.24) |
| None | 26 (8.0) | 19 163 (11.8) | 0.11 (0.07-0.15) | 0.14 (0.09-0.20) |
| Asthma and allergyc | 50 (15.3) | 17 885 (11.0) | 0.21 (0.16-0.28) | 0.28 (0.21-0.37) |
| No asthma and allergy | 276 (84.7) | 144 172 (89.0) | 0.15 (0.13-0.17) | 0.19 (0.17-0.22) |
| Psychiatric conditionsd | 58 (17.8) | 20 667 (12.8) | 0.21 (0.16-0.27) | 0.28 (0.21-0.36) |
| No psychiatric conditions | 268 (82.2) | 141 390 (87.2) | 0.15 (0.13-0.16) | 0.19 (0.17-0.21) |
| Diabetese | 2 (0.6) | 762 (0.5) | 0.19 (0.02-0.68) | 0.26 (0.05-1.05) |
| No diabetes | 324 (99.4) | 161 295 (99.5) | 0.15 (0.14-0.17) | 0.20 (0.18-0.22) |
| Acute COVID-19 care level | ||||
| Hospitalizedf | 11 (3.4) | 518 (0.3) | 1.25 (0.62-2.23) | 2.08 (1.10-3.80) |
| Nonhospitalized | 315 (96.6) | 161 539 (99.7) | 0.15 (0.13-0.17) | 0.20 (0.17-0.22) |
| MIS-Cg | 6 (1.8) | 57 (<0.1) | 5.81 (2.13-12.64) | 9.52 (3.93-20.24) |
| No MIS-C | 320 (98.2) | 162 000 (>99.9) | 0.15 (0.14-0.17) | 0.20 (0.18-0.22) |
| Virus varianth | ||||
| Mix of virus variants | 143 (43.9) | 28 982 (17.9) | 0.24 (0.20-0.28) | 0.49 (0.42-0.58) |
| Alpha | 88 (27.0) | 40 192 (24.8) | 0.13 (0.11-0.16) | 0.22 (0.18-0.27) |
| Delta | 48 (14.7) | 26 894 (16.6) | 0.16 (0.12-0.22) | 0.18 (0.13-0.24) |
| Omicron | 47 (14.4) | 65 989 (40.7) | 0.08 (0.06-0.11) | 0.07 (0.05-0.10) |
| Parents’ maximum education | ||||
| Primary school | 8 (2.5) | 6077 (3.7) | 0.10 (0.04-0.19) | 0.13 (0.06-0.27) |
| Secondary school | 84 (25.8) | 38 260 (23.6) | 0.16 (0.13-0.20) | 0.22 (0.18-0.27) |
| Tertiary school | 165 (50.6) | 81 962 (50.6) | 0.15 (0.13-0.18) | 0.20 (0.17-0.24) |
| Unknown | 69 (21.2) | 35 758 (22.1) | 0.15 (0.12-0.20) | 0.19 (0.15-0.25) |
| Any parent diagnosed with PCC | ||||
| Yes | 35 (10.7) | 3401 (2.1) | 0.70 (0.49-0.97) | 1.02 (0.72-1.43) |
| No | 291 (89.3) | 158 656 (97.9) | 0.14 (0.13-0.16) | 0.18 (0.16-0.21) |
Abbreviations: MIS-C, multisystem inflammatory syndrome in children; PCC, post–COVID-19 condition.
At study start (January 31, 2020).
Defined as any diagnosis International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) code during 2018-2019.
Defined as ICD-10 code J30 or J45 during 2018-2019.
Defined as ICD-10 code F00-F99 during 2018-2019.
Defined as ICD-10 code E10-E14 during 2018-2019.
Including both hospitalization at intensive care units (0 and 40) and regular wards (11 and 478).
Defined as ICD-10 code U10.9. A total of 6 children received both a PCC diagnosis and MIS-C diagnosis, with 4 receiving a PCC diagnosis more than 28 days after MIS-C diagnosis.
Dominant virus variant during the time period when the acute COVID-19 infection occurred.