Table 3. Slope Difference Scores and Between-Condition Effect Sizes for Intent-to-Treat (ITT) and Per-Protocol (PP) Analyses.
| CXA-UP vs WL difference slope | Treatment effect size CXA-UP vs WL | |||||||
|---|---|---|---|---|---|---|---|---|
| ITT | PP | ITT | PP | |||||
| Slope (SE) | t Value | df a | Slope (SE) | t Value | df a | Cohen d (90% CI)b | Cohen d (90% CI)b | |
| Primary outcomes | ||||||||
| PCL-5 score | −31.12 (3.00)c | −10.35 | 150 | −29.89 (3.24)c | −9.21 | 109 | 0.90 (0.63-1.19) | 0.95 (0.63-1.28) |
| PHQ-depression score | −11.94 (1.30)c | −9.17 | 146 | −11.33 (1.39)c | −8.14 | 107 | 0.77 (0.52-1.06) | 0.82 (0.49-1.15) |
| PHQ-anxiety score | −6.52 (0.67)c | −9.71 | 143 | −6.25 (0.72)c | −8.61 | 107 | 0.82 (0.56-1.09) | 0.87 (0.56-1.22) |
| PHQ-somatic score | −8.31 (0.92)c | −9.00 | 150 | −7.97 (0.99)c | −7.98 | 108 | 0.75 (0.47-1.04) | 0.80 (0.47-1.12) |
| Secondary outcomes | ||||||||
| ODSIS score | −10.02 (0.97)c | −10.24 | 154 | −9.63 (1.06)c | −9.08 | 109 | 0.87 (0.61-1.15) | 0.95 (0.61-1.28) |
| OASIS score | −9.43 (0.93)c | −10.12 | 124 | −9.55 (0.94)c | −10.10 | 109 | 1.01 (0.68-1.32) | 1.09 (0.75-1.42) |
| QLESQ score | 10.85 (1.53)c | 7.06 | 140 | 10.48 (1.63)c | 6.41 | 109 | 0.54 (0.28-0.80) | 0.56 (0.28-0.87) |
| WHODAS score | −1.01 (0.14)c | −7.06 | 119 | −1.00 (0.14)c | −6.76 | 100 | 0.61 (0.32-0.90) | 0.65 (0.35-0.98) |
Abbreviations: CXA-UP, contextual/cultural adaptation of the Unified Protocol; OASIS, Overall Anxiety Severity and Impairment Scale; ODSIS, Overall Depression Severity and Impairment Scale; PHQ, Patient Health Questionnaire; PCL-5, posttraumatic stress disorder checklist for DSM-5; QLESQ, Quality-of -Life Enjoyment and Satisfaction Questionnaire; WHODAS, World Health Organization Disability Assessment Scale; WL, waitlist.
a
df and P values are derived with the Satterthwaite method.
b
The Cohen d effect sizes presented are transformations of η2 P to a more common effect size measure (interpretation: 0.2 small, 0.5 medium, 0.8 large).
c
P < .001.