Table 5. . Multivariate analysis for PFS and OS.

Characteristic	HR for PFS (95% CI)	p-value	HR for OS (95% CI)	p-value
Stage at diagnosis (M1 vs M0)	2.68 (1.45–4.93)	<0.01	2.29 (1.11–4.75)	0.02
Bone M (Yes vs No)	2.00 (0.99–4.07)	0.06	3.81 (1.76–8.25)	<0.01
Bellmunt score   0   1   2   3	– 1.12 (0.51–2.49) 1.13 (0.51–2.51) 5.27 (1.46–19.1)	– 0.76 0.77 0.01	– 1.14 (0.49–2.65) 1.29 (0.50–3.30) 6.19 (1.67–22.9)	0.76 0.59 <0.01
NLR (<3 vs >3)	0.72 (0.41–1.29)	0.27	0.49 (0.25–0.95)	0.03

Bold values are statistically significant.

M: Metastasis; NLR: Neutrophil-to-lymphocyte ratio.