Table 1. Structure and Antimycobacterial Activity of the 25 N,N′-Diphenylterephthalamide Derivatives Belonging to the Focused Small Library Built around the Hit Compound NSC55150 (22).

compound	R	MIC (μg/mL)
1, NSC73489	H	20–40
2, NSC164131	o-F	>40
3, NSC111339	p-F	>40
4, NSC73488	p-Cl	>40
5, NSC204225	m,p-di-Cl	>40
6, NSC71193	p-Me	>40
7, NSC110298	p-Et	>40
8, NSC110302	m-Cl,p-Me	>40
9, NSC110317	p-FSO2	>40
10, NSC55146	p-C(=NH)NH2	>40
11, NSC53313	p-C(=NH)NHCH3	0.31
12, NSC70138	p-C(=NH)NHCH2CH3	0.62
13, NSC71201	p-C(=NH)NH(CH2)2CH3	0.62
14, NSC80122	p-C(=NH)NHCH(CH3)2	0.62
15, NSC80976	p-C(=NH)NH(CH2)3CH3	1.25
16, NSC80975	p-C(=NH)NH(CH2)5CH3	5
17, NSC53312	p-C(=NCH3)NHCH3	0.62
18, NSC64897	p-C(=NH)NHNH2	>40
19, NSC77889		10
20, NSC55148		>10
21, NSC55147		>40
22, NSC55150	p-CH2C(=NH)NH2	1
23, NSC55151	p-NHC(=NH)NH2	0.16
24, NSC72583		2.5
25, NSC65376		0.62