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. 2023 Jul 3;8(28):25209–25220. doi: 10.1021/acsomega.3c02311

Table 2. Whole-Cell Target-Based Screena.

  MIC (μg/mL)
Mtb strains 22 23 11 streptomycin
H37Rv 1 0.3 0.25 0.25
TB71 0.25 0.03–0.06 0.125 0.25
TB173 Pi [25 ng/mL] 0.125 0.06 0.125 0.25
TB173 Pi [15 ng/mL] 0.125 0.01 0.125 0.25
a

Activity of 22 and its derivatives against Mtb H37Rv, parental TB71, and conditional mutant TB173 strains (determined by REMA).