Table 2.

Lessons from SPRINT trial and SPRINT MIND substudy. Target for intensive systolic BP control was <120 mm Hg and for standard systolic BP control <140 mm Hg.

Clinical outcomes
Wright et al 89	Intensive BP therapy did not reduce risk of stroke but did reduce all-cause mortality by 27%.
Williamson et al92	Intensive BP group had a significantly reduced risk of MCI and composite endpoint of MCI and dementia compared to standard group.
Rapp et al94	No clinically significant difference was observed between intensive and standard treatment groups for memory or processing speed.
Radiographic and physiological outcomes
Nasrallah et al95	Intensive BP group had 0.54cm3 less increase in white matter lesion volume than the standard group over a median follow-up of 3.40 years.
Goldstein et al96	SPRINT-MIND post hoc analysis showed that use of ACE inhibitors was most consistently associated with decreased white matter progression.
Nasrallah et al95	Intensive BP group had 3.7 cm3 less total brain volume loss than standard BP group.
Dolui et al97	Intensive BP group had 2.30 ml/100g/min higher whole brain perfusion change than standard BP group.

BP denotes blood pressure; MCI, mild cognitive impairment.