Comparison 2. Adults using 80/4.5 mcg BDF single inhaler therapy versus usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Patients with exacerbations causing hospitalisation	1	102	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Patients with exacerbations treated with oral steroids	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3 Serious adverse events (fatal)	1	102	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Serious adverse events (non‐fatal)	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5 Discontinuation due to adverse events	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
6 ICS dose (micrograms per day BDP equivalent)	1		Mean Difference (Fixed, 95% CI)	Totals not selected