Table 2.
Target genes and associated regulatory networks for differentially expressed miRNAs between PD and controls.
| Upregulated in PD | Log2 (Fold-Change) | FDR | Average expression | P-value |
|---|---|---|---|---|
| hsa-miR-26b-5p | 9.804 | 5.74E-7 | 12.048 | 8.16E-9 |
| RNA5SP382 | 7.874 | 5.74E-7 | 9.955 | 1.59E-8 |
| hsa_piR_009295 | 6.851 | 9.25E-7 | 9.451 | 3.42E-8 |
| hsa_piR_020498 | 5.993 | 7.14E-5 | 9.634 | 4.63E-6 |
| hsa_piR_020492 | 4.851 | 1.804 | 9.979 | 2.84E-4 |
| hsa-miR-181a-5p | 4.758 | 7.64E-3 | 13.196 | 1.42E-3 |
| hsa_piR_016658 | 4.702 | 2.70E-3 | 14.593 | 4.51E-4 |
| hsa-miR-25-3p | 4.119 | 2.01E-2 | 11.630 | 4.37E-4 |
| hsa-miR-191-5p | 3.987 | 2.36E-2 | 12.683 | 5.68E-3 |
| hsa_piR_004153 | 3.718 | 5.65E-4 | 9.442 | 7.85E-5 |
| p-hsa-miR-330 | 3.550 | 4.36E-2 | 12.791 | 1.17E-2 |
| hsa-miR-6,073 | 3.464 | 1.06E-4 | 8.159 | 9.83E-6 |
| hsa-miR-221-3p | 3.406 | 2.36E-2 | 9.901 | 5.51E-3 |
| hsa-miR-21-5p | 3.177 | 2.79E-2 | 14.211 | 6.99E-3 |
| RNA5SP259_RNA5SP25 | 3.175 | 1.42E-6 | 6.693 | 6.56E-8 |
| hsa_piR_004150 | 2.898 | 2.99E-4 | 7.369 | 3.53E-5 |
| RNU6-1300P | 2.823 | 2.99E-4 | 6.928 | 3.84E-5 |
| hsa_piR_019825 | 2.731 | 3.01E-3 | 9.155 | 5.3E-4 |
| hsa_piR_015068 | 2.400 | 1.70E-3 | 7.000 | 2.52E-4 |
| RNA5-8SP6 | 2.248 | 2.99E-4 | 6.591 | 3.88E-5 |
| hsa_piR_004152 | 1.981 | 2.4E-4 | 6.493 | 2.44E-5 |
| RNA5SP263_RNA5SP26 | 1.893 | 2.01E-2 | 6.531 | 4.46E-3 |
| Down-regulated in PD | Log2 (Fold-Change) | FDR | Average Expression | P-value |
|---|---|---|---|---|
| hsa_piR_005019 | −7.375 | 5.03E-6 | 12.808 | 2.80E-7 |
| hsa_piR_017754 | −5.959 | 7.37E-5 | 8.617 | 5.46E-6 |
| RNA5-8SP4 | −3.011 | 5.74E-7 | 6.665 | 1.46E-8 |
| hsa_piR_002468 | −2.723 | 1.80E-2 | 9.047 | 3.67E-3 |
| RNA5SP485 | −2.656 | 8.48E-5 | 6.785 | 7.06E-6 |
| hsa_piR_022606 | −1.575 | 8.74E-3 | 6.443 | 1.7E-3 |
| hsa_piR_007362 | −1.169 | 4.37E-2 | 6.470 | 1.15E-2 |