Table 3.
Association of smRNAs with clinical parameters.
| LASSO selected predictor variables | Coefficient value | p-value | Clinical parameter | Control range | PD range |
|---|---|---|---|---|---|
| - | - | - | Age at Visit | 43–86 | 43.6–93 |
| - | - | - | Disease Duration (years) | 0 | 0–32 |
| hsa-miR-21-5p | 1.96E-04 | 0.227 | Hoehn and Yahr Stage | 0–3 | 1–5 |
| - | - | - | MoCA | 21–30 | 9–29 |
| RNA5SP382 | −3.01E-04 | 0.891 | Hamilton Depression Scale | 0–12 | 0–21 |
| hsa-miR − 181a-5p | 2.81E-04 | 0.840 | |||
| hsa_piR_016658 | 1.36E-03 | 0.129 | |||
| hsa-miR-25-3p | -1.25E-03 | 0.624 | |||
| hsa-miR-191-5p | −4.70E-03 | 0.139 | |||
| hsa-miR-21 − 5p | -5.10E-05 | 0.923 | |||
| hsa_piR_005019 | −2.69E-03 | 0.156 | |||
| - | - | - | Total UPDRS | 0–27 | 3–98 |
| - | - | - | Education (Years) | 8–23 | 7–21 |
LASSO was used to select the smRNAs for regression to test the association between smRNA expression levels and clinical parameters: age at visit, disease duration, Hoehn and Yahr stage, MoCA, Hamilton depression score, total MDS-UPDRS, and education (years). PD clinical parameters are listed along with the smRNAs tested for association (of the 29 smRNAs in the panel expressed differentially in PD and control subjects). The outcomes without predictor variables had all of the coefficients of the 29 smRNA variables shrunk down to zero. They are represented as a dash, thereby not having any smRNA predictors tested for association via regression.