. 2023 Jul 5;8(28):25048–25058. doi: 10.1021/acsomega.3c01686

Table 2. Aedes aegypti Larvicidal Activity (μg/mL) of Oxoquinazolines^e.

compound	LC₅₀	LC₉₀	χ²	p
4a	24 h
	5.819 (5.358–6.391)	8.528 (7.729–9.730)	1.57	0.456
	48 h
	3.663 (3.271–4.078)	6.396 (5.755–7.334)	0.00144	0.999
	72 h
	2.261 (1.723–2.693)	5.273 (4.620–6.340)	4.02	0.134
	96 h
	1.486 (0.704–1.984)	4.470 (3.864–5.530)	0.953	0.621
4b	24 h
	12.68 (11.32–14.16)	31.11 (26.90–37.20)	19.71	0.001
	48 h
	3.642 (3.270–4.042)	7.610 (6.607–9.160)	5.76	0.218
	72 h
	3.476 (3.134–3.846)	6.945 (6.055–8.327)	4.21	0.379
	96 h
	^a	^a
4c	24 h
	15.06 (12.70–18.02)	^b	10.20	0.017
	48 h
	10.11 (8.10–12.38)	^b	7.37	0.061
	72 h
	4.423 (2.770–6.030)	^b	3.78	0.286
	96 h
	1.799 (0.574–3.188)	^b	2.59	0.459
4d	24 h
	52.38 (36.87–88.24)	^b	14.79	0.005
	48 h
	22.73 (16.39–35.22)	^b	11.40	0.022
	72 h
	4.201 (1.867–6.900)	^b	5.59	0.232
	96 h
	^c	^c
4e	24 h
	9.252 (8.156–10.562)	25.81 (21.16–33.50)	5.66	0.129
	48 h
	4.274 (3.643–4.966)	16.26 (12.95–22.06)	7.96	0.047
	72 h
	2.756 (2.219–3.294)	12.27 (9.67–17.09)	7.77	0.051
	96 h
	1.280 (0.801–1.729)	7.414 (5.780–10.598)	1.83	0.609
4f	24 h
	8.671 (7.863–9.617)	14.67 (13.22–16.69)	4.22	0.239
	48 h
	5.921 (4.944–6.924)	14.33 (12.51–17.09)	1.03	0.795
	72 h
	2.085 (0.418–3.258)	11.29 (9.56–14.17)	0.816	0.846
	96 h
	^a	^a
4g	not soluble
4h	>50 (96 h)	>50 (96 h)	^d	^d
4i	not soluble
permethrin	24 h	24 h	4.64	0.031
permethrin	0.000643 (0.000551–0.000753)	0.00246 (0.00192–0.00344)	4.64	0.031

LC₅₀ and LC₉₀ not reliable; >50% lethality at the lowest concentration.

LC₉₀ values not reliable; <90% lethality at the highest concentration.

Lethality too flat across the different concentrations, not dose-dependent.

Not defined.

χ²: goodness of fit. p: determined by comparison between the probabilities based on the experimental data and the probabilities from the model.

Table 2. Aedes aegypti Larvicidal Activity (μg/mL) of Oxoquinazolinese.