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. 2023 Jul 20;23:680. doi: 10.1186/s12885-023-11176-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Uptake of TFO by different breast cancer cell lines. A. TFO is designed to bind to a polypurine sequence located in the exon of the HER2 gene. The HER2-11074 used in this article was designed to bind to a region between exon 23 and 24. B. Western blot analysis of HER2 protein levels in breast cancer cell lines with different gene copy numbers. C. Quantification indicated the level of HER2 in these cells. Data are presented as mean ± SEM and were analyzed by Tukey's post hoc test; Error bars represent SEM of the technical replicates (3 biological replicates with at least 2 technical replicates each). *, P = 0.03, BT474 compared with other cells; N = 3 independent experiments. D. Gene copy number characteristics of breast cancer cell lines. E. Confocal images show the nucleation of TFO in different breast cancer cells. The red fluorescence indicates the TAMRA-tagged TFO fragment (Scale bar = 50 μm)