Table 3.

Multiple mixed linear effect regression of log-transformed TMAO levels with Empagliflozin versus placebo and other variables

Variables	Coefficient ± SEM	P-value
Visit
Baseline	Reference
6 weeks	0.254 ± 0.043	0.041
26 weeks	0.326 ± 0.043	0.005
Treatment group
Placebo	Reference
Empagliflozin	0.117 ± 0.035	0.001
Age—5 years change	0.023 ± 0.011	0.042
eGFR—10 mL/min/1.73 m2 change	− 0.025 ± 0.011	0.023
LVEF—5% change	− 0.023 ± 0.011	0.035

eGFR: estimated glomerular filtration rate, LVEF: left ventricular ejection fraction, SEM: standard error of mean