Table 5.

Univariable and multivariable linear regression analysis of early and current life factors and proteins of interest in POLD compared to PT_c

Variable	MMP9			S100A8			CTSC
	Beta	SE	p-value	Beta	SE	p-value	Beta	SE	p-value
Univariable Models
Sex, ref = Male	0.15	0.10	0.15	-0.42	0.26	0.11	-0.02	0.13	0.88
Age at testing, years	-0.01	0.04	0.72	-0.04	0.09	0.65	0.01	0.05	0.78
IUGR ref = No IUGR	-0.02	0.13	0.90	0.32	0.34	0.36	-0.10	0.17	0.55
BPD ref = No BPD	-0.26	0.11	0.017*	0.38	0.28	0.17	-0.03	0.15	0.85
POLD ref = PTc	-0.30	0.13	0.025*	-0.69	0.34	0.043*	-0.31	0.16	0.058
Multivariable Models
BPD ref = No BPD	-0.26	0.11	0.017*	Not taken forward for multivariable model			Not taken forward for multivariable model
POLD ref = PTc	-0.30	0.13	0.024*

SE: Standard error; IUGR: Intrauterine growth restriction; BPD: Bronchopulmonary dysplasia, POLD: prematurity-associated obstructive lung disease, PT_c: preterm-born controls. Multivariable models only created where ≥ 2 univariable models had a p-vale < 0.1

Bold*: p value < 0.05 Italic: p value < 0.1