Table 2.

Association between prognostic factors and outcomes described in the reviews

Prognostic factors	(+)	(+/−)	(−)	Total number of reviews
Biomarkers	3 (50, 54, 58)	9 (2, 5, 26, 27, 44, 47, 52, 55, 56)		12
Sex	3 (24, 25, 53)	4 (5, 18, 19, 56)	1 (48)	8
Age	3 (2, 24, 25)	3 (19, 48, 56)		6
Multiple concussions	2 (46, 49)	3 (19, 52, 56)	1 (22)	6
Negative perceptions/expectations	3 (2, 5, 22)	1 (56)		4
Somatic complaints	2 (2, 48)	2 (19, 56)		4
Litigation/financial compensation	2 (2, 19)	1 (45)		3
Mental health (pre-injury)	2 (2, 56)	1 (19)		3
Extracranial injuries	2 (17, 48)	1 (56)		3
Level of education	2 (2, 48)	1 (56)		3
Anxiety/depression	2 (2, 56)		1 (5)	3
PTSD	2 (17, 19)		1 (5)	3
LOC		1 (5)	2 (2, 56)	3
Nausea/vomiting	1 (48)	1 (19)		2
Marital status	1 (2)	1 (19)		2
Memory of the injury event	1 (2)	1 (5)		2
Physical health (pre-injury)	1 (56)	1 (19)		2
PTA		2 (2, 56)		2
Mechanism of injury		1 (19)	1 (56)	2
Acute stress disorder (ASD)	1 (19)			1
Baseline mental/physical health	1 (2)			1
Degree of trait of resilience	1 (57)			1
Baseline noise sensitivity	1 (2)			1
Job independence/decision-making latitude at work	1 (48)			1
Gross national product of the country	1 (2)			1
Pre-injury fatigue	1 (2)			1
Being a student		1 (19)		1
Being sober/intoxicated in ED		1 (56)		1
Quality of sleep		1 (51)		1
Prior neurological problems		1 (19)		1
Life stressors		1 (19)		1
Complicated mTBI		1 (19)		1
Sensory motor test		1 (56)		1
Cognitive/neuropsychological tests		1 (56)		1
Glasgow Coma Scale score			1 (56)	1

ED Emergency department, LOC Loss of consciousness, mTBI Mild traumatic brain injury, PTA Post-traumatic amnesia, PTSD Post-traumatic stress disorder