Table 2.

Gene Ontology annotations of tick saliva proteins associated with AGS

Tick proteins	Cellular component	Molecular function	Biological process
Alpha-macroglobulin	Extracellular region or secreted	Endopeptidase inhibitor activity	Complement activation
Angiotensin-converting enzyme Cofactor: Zn2+	Membrane	Carboxypeptidase activity Metal ion binding Metallopeptidase activity Peptidyl-dipeptidase activity	Regulation of inflammatory response, cytokine production, transmembrane transporter activity
Vitellogenin	Membrane	Glycosyltransferase activity Lipid transporter activity	Cellular response to heat, estradiol, insulin, polycyclic arene
Metalloprotease	Membrane	Metallopeptidase activity	Membrane protein ectodomain proteolysis
Actin	Cytoskeleton Nucleus	ATP binding Constituent of cytoskeleton	Mitotic cytokinesis Substantia nigra development Regulation of transmembrane transporter activity
Anticoagulant	Extracellular region and/or exosome	Unknown	Blood coagulation
Serpin	Extracellular region or secreted	Protein serine kinase activity Serine-type endopeptidase inhibitor activity	Negative regulation of endopeptidase activity, protein processing
Secreted protein B7P904	Secreted	Protein serine/threonine phosphatase activity
Secreted protein B7P208-Salivary antigen p23	Secreted	Match to 3UV1_A Chain(A) PDB structure. Allergen from dust mite, Dermatophagoides farinae (DOI:10.2210/pdb3UV1/pdb) Bactericidal permeability-increasing protein