Table 3.

Tick salivary proteins associated with allergic reactions, AGS, or acquired resistance to tick infestations

Tick proteins	Signs associated with AGS in zebrafish model	Association with allergy, AGS in humans	Association with acquired resistance to tick infestations	α-Gal-positive	References
Alpha-macroglobulin	Hemorrhagic type allergic reactions	Yes	Yes	Yes	[13, 34, 41, 54, 55]
Vitellogenin	Hemorrhagic type allergic reactions	Yes	No	Yes	[13, 55]
Metalloprotease	Hemorrhagic type allergic reactions, abnormal behavior pattern, and mortality	Yes	No	No	[55]
Actin	Abnormal behavior pattern	Yes	No	No	[13, 55]
Anticoagulant	Abnormal or no feeding	No	Yes	Unknown	[34, 54]
Serpin	Abnormal behavior pattern	No	Yes	Yes	[34, 54, 55]
Secreted protein B7P208-Salivary antigen p23 (allergen)	Hemorrhagic type allergic reactions and mortality	Yes	No	Unknown	[55, 56]