Table 3.
Univariate and multivariable Cox regression models addressing the prediction of cancer-specific survival after radical cystectomy for urothelial carcinoma of the bladder
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Age | 1.015 (0.983–1.047) | 0.357 | – | – |
| Gender (ref. men) | 1.109 (0.343–3.584) | 0.863 | – | – |
| BMI | 0.961 (0.897–1.029) | 0.254 | – | – |
| Sarcopenia (ref. absence) | 2.155 (1.153–4.028) | 0.016 | 2.841 (1.425–5.664) | 0.003 |
| CCI CCI: 3–4 (ref. <3) CCI: ≥5 (ref. <3) |
0.666 (0.253–1.752) 1.018 (0.373–2.781) |
0.410 0.972 |
– | – |
| ASA score ≥3 (ref. ≤2) | 1.816 (0.981–3.361) | 0.058 | – | – |
| pT stage pT2 (ref. ≤pT1) pT3 (ref. ≤pT1) pT4 (ref. ≤pT1) |
3.377 (0.739–15.425) 7.100 (1.629–30.942) 12.754 (2.873–56.622) |
0.116 0.009 0.001 |
3.259 (0.698–15.218) 4.571 (0.991–21.073) 8.059 (1.550–41.990) |
0.133 0.051 0.013 |
| pN stage pN+ stage (reference: pN0/x) |
1.747 (0.881–3.462) | 0.110 | – | – |
| Preoperative albumin | 0.966 (0.603–1.548) | 0.886 | – | – |
| Preoperative creatinine | 1.381 (0.791–2.413) | 0.256 | – | – |
| Preoperative haemoglobin | 0.924 (0.767–1.112) | 0.403 | – | – |
| Adjuvant chemotherapy (reference: not administered) | 1.274 (0.688–2.359) | 0.441 | – | – |
| Presence of LVI (ref. absence) | 2.979 (1.612–5.504) | <0.001 | 1.794 (0.882–3.648) | 0.107 |
| Perioperative complication (ref. absence) | 2.882 (1.120–7.416) | 0.028 | 2.051 (0.743–5.659) | 0.165 |
| Positive STSM (ref. absence) | 2.792 (1.353–5.761) | 0.005 | 1.624 (0.709–3.722) | 0.252 |
| Postoperative blood transfusion (ref. absence) | 1.040 (0.574–1.984) | 0.897 | – | – |
CI – confidence interval; CCI – Charlson comorbidity index; LVI – lymphovascular invasion; STSM – soft tissue surgical margin