Fig. 7. (A) Plot showing the StarDrop (Optibrium, Ltd., Cambridge, UK)-derived log S versus a multimetric oral non-CNS profile score. Importance: log S = 0.9, HIA = 0.85, log P = 0.6, log D = 0.6, hERG pIC50 = 0.4, 2D6 affinity category = 0.3, 2C9 pKi = 0.3, P-gp category = 0.3, PPB90 category = 0.2, BBB category = 0.11, BBB log(brain : blood) = 0.11 (B) P-gp category, (C) PPB90 = plasma protein binding >90%, (D) HIA = human intestinal absorption category, and probability of prediction of F-Id-3k, F-Id-3o, I3o and PF74.
