Fig. 9. Genotoxicity and hepatotoxicity endpoints for selected compounds. The highlighted table shows the StarDrop V7 (Optibrium, Ltd., Cambridge, UK)-derived toxicity endpoints using the Derek Nexus module based on a knowledge-based prediction. Structural alerts within the molecule with a level of likelihood for concerns are based on precedence from experimental data. Likelihood level 0 = no report; 1 = inactive; 2 = equivocal; 3 = plausible; 4 = probable. Ethyl methanesulfonate (EMS) was used as a positive control for genotoxicity,58 and lumiracoxib as a positive control for hepatotoxicity endpoints.59.
