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(A) An early prephagocytic stage in the formation of a new plaque in a patient with exceptionally early multiple sclerosis. (B) The whole plaque consists of a mass of elongated cells resembling wall microglia. Monocytes and myelin phagocytes were present in small numbers mainly at the at the edge of the lesion (Case 2, plaque 1, CD45, A, ×25, B, ×200).
