Table 3.
Microglia and macrophages
| CD45 | RCA1 | MHC II | CD16 | IgG | CD68 | MRP14 | HAM56 | |
|---|---|---|---|---|---|---|---|---|
| Resident microglia | + | ± to + | o to ± | o | o | ± to + | o | o |
| Reactive microglia | + | ± to + | o to ± | ± | o | ± to + | o | o |
| Demyelinated tissue | ||||||||
| Corralling | ||||||||
| Reticulate | ||||||||
| Mitotic | ||||||||
| Perivascular microglia | ||||||||
| Activated microglia | + | * | + | ± | o | ± | o | o |
| Transitioning | ||||||||
| Phagosomes | ||||||||
| MHCll | ||||||||
| Perivascular microglia | ||||||||
| Wall microglia | + | ± | + | * | o to ± | * | o | ± |
| Blood-brain barrier | ||||||||
| Nodules of microglia | + | * | o to + | o to ± | o | o to + | o to + | * |
| C3d | ||||||||
| Microglia/monocyte | ||||||||
| Compacted | ||||||||
| Ensheathed monocytes | ||||||||
| Residual microglia | * | * | * | * | * | * | * | * |
| Phagocytic macrophages | + | o | + | * | + | + | + | + |
| Round and amoeboid | ||||||||
| Phagosomes | ||||||||
| Proliferation | ||||||||
| Spindle shaped | ||||||||
| Perivascular demyelination | ||||||||
| Foamy macrophages | + | + | + | o to + | o to ± | + | o to + | ± to + |
| Remyelination |
Resident and reactive: microglia with branching processes. Activated: nonramified MHC ll-positive microglia. Wall microglia: wall-forming microglia. Nodules: aggregates of microglia. Residual: parenchymal phagocytes with distinctive secondary lysosomes observed in chronic cases of multiple sclerosis. Probably microglia in origin. Currently no reliable immunohistochemical data available. Phagocytic: cells with Luxol Fast Blue (LFB)-positive particles of myelin. Foamy macrophages: LFB-negative cells distended with lipids.
+, positive; ±, variable; o, negative; *, not known.