Table 3:
Non-hematologic Grade 3-5 adverse events attributed to dose-adjusted EPOCH.
| CTCAE Category | Grade 3 | Grade 4 | Grade 5 |
|---|---|---|---|
| Febrile Neutropenia | 21 | ||
| Sepsis | 10 | 1 | |
| Mucositis Oral | 8 | ||
| Miscellaneous Infectiona | 6 | ||
| Upper Gastrointestinal Hemorrhage | 2 | 1 | |
| Hypotension | 3 | ||
| Atrial fibrillation | 2 | ||
| Hypertension | 2 | ||
| Intracranial hemorrhage | 2 | ||
| Multiorgan Failure | 1 | ||
| Abdominal pain | 1 | ||
| Aspiration | 1 | ||
| Delirium | 1 | ||
| Diarrhea | 1 | ||
| Edema Limbs | 1 | ||
| Fibrinogen decreased | 1 | ||
| Hypoxia | 1 | ||
| Lower gastrointestinal hemorrhage | 1 | ||
| Myocardial Infarction | 1 | ||
| Oropharyngeal pain | 1 | ||
| Peripheral Motor Neuropathy | 1 | ||
| Sinus Bradycardia | 1 | ||
| Small Intestinal Obstruction | 1 |
a
This category includes the following events: enterocolitis (n = 2), endophthalmitis (n = 1), fungemia (n = 1), kidney infection (n = 1), and typhlitis (n = 1).
Note: blank cells denote zero instances of those events at those grades.