Table 1.
Demographic and tumor characteristics of breast cancer cases by histologic type
| Characteristic | Ductal n = 255,718 | Ductal-lobular n = 26,900 | Lobular n = 21,062 | Mucinous n = 6,561 | Tubular n = 4,477 | Inflammatory n = 2,673 | Medullary n = 2,072 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | % | n | % | n | % | n | % | |
| Age at diagnosis, years | ||||||||||||||
| 30–39 | 15,959 | 6.2 | 1,075 | 4.0 | 402 | 1.9 | 227 | 3.5 | 88 | 2.0 | 253 | 9.5 | 296 | 14.3 |
| 40–49 | 52,012 | 20.3 | 5,251 | 19.5 | 3,218 | 15.3 | 811 | 12.4 | 784 | 17.5 | 587 | 22.0 | 648 | 31.3 |
| 50–59 | 64,076 | 25.1 | 7,173 | 26.7 | 4,973 | 23.6 | 1,018 | 15.5 | 1,295 | 28.9 | 778 | 29.1 | 556 | 26.8 |
| 60–69 | 55,036 | 21.5 | 6,171 | 22.9 | 5,084 | 24.1 | 1,331 | 20.3 | 1,167 | 26.1 | 510 | 19.1 | 329 | 15.9 |
| 70–79 | 45,123 | 17.6 | 4,926 | 18.3 | 4,700 | 22.3 | 1,895 | 28.9 | 833 | 18.6 | 337 | 12.6 | 173 | 8.3 |
| 80+ | 23,512 | 9.2 | 2,304 | 8.6 | 2,685 | 12.7 | 1,279 | 19.5 | 310 | 6.9 | 208 | 7.8 | 70 | 3.4 |
| Mean ± standard deviation | 59.7 ± 13.9 | 60.4 ± 13.1 | 63.5 ± 13.2 | 66.5 ± 14.2 | 60.8 ± 12.0 | 57.3 ± 13.9 | 52.8 ± 12.8 | |||||||
| Year of diagnosis | ||||||||||||||
| 1992–1995 | 32,125 | 12.6 | 1,954 | 7.3 | 1,593 | 7.6 | 559 | 8.5 | 433 | 9.7 | 354 | 13.2 | 410 | 19.8 |
| 1996–1999 | 44,166 | 17.3 | 3,868 | 14.4 | 3,233 | 15.3 | 1,038 | 15.8 | 861 | 19.2 | 536 | 20.1 | 422 | 20.4 |
| 2000–2003 | 84,495 | 33.0 | 10,462 | 38.9 | 7,142 | 33.9 | 2,331 | 35.5 | 1,719 | 38.4 | 1125 | 42.1 | 678 | 32.7 |
| 2004–2007 | 94,932 | 37.1 | 10,616 | 39.5 | 9,094 | 43.2 | 2,633 | 40.1 | 1,464 | 32.7 | 658 | 24.6 | 562 | 27.1 |
| Mean follow-up time ± standard deviation, months | 61.0 ± 46.1 | 57.8 ± 40.6 | 54.7 ± 41.6 | 58.8 ± 42.2 | 67.9 ± 43.5 | 40.2 ± 35.7 | 76.3 ± 50.3 | |||||||
| SEER registry | ||||||||||||||
| Alaska natives | 329 | 0.1 | 37 | 0.1 | 21 | 0.1 | 5 | 0.1 | 1 | 0.0 | 4 | 0.1 | 5 | 0.2 |
| Atlanta | 12,350 | 4.8 | 772 | 2.9 | 695 | 3.3 | 211 | 3.2 | 155 | 3.5 | 126 | 4.7 | 77 | 3.7 |
| Connecticut | 17,624 | 6.9 | 2,060 | 7.7 | 1,683 | 8.0 | 467 | 7.1 | 334 | 7.5 | 148 | 5.5 | 206 | 9.9 |
| Detroit | 17,481 | 6.8 | 1,771 | 6.6 | 1,439 | 6.8 | 355 | 5.4 | 303 | 6.8 | 101 | 3.8 | 174 | 8.4 |
| Greater California | 45,584 | 16.5 | 5,442 | 20.2 | 4,010 | 19.0 | 1,164 | 17.7 | 714 | 15.9 | 534 | 20.0 | 257 | 12.4 |
| Hawaii | 7,219 | 2.8 | 265 | 1.0 | 339 | 1.6 | 211 | 3.2 | 126 | 2.8 | 24 | 0.9 | 38 | 1.8 |
| Iowa | 16,633 | 6.5 | 1,087 | 4.0 | 1,358 | 6.4 | 399 | 6.1 | 241 | 5.4 | 168 | 6.3 | 134 | 6.5 |
| Kentucky | 9,316 | 3.6 | 692 | 2.6 | 767 | 3.6 | 223 | 3.4 | 162 | 3.6 | 112 | 4.2 | 41 | 2.0 |
| Los Angeles | 30,517 | 11.9 | 4,988 | 18.5 | 2,419 | 11.5 | 1,005 | 15.3 | 736 | 16.4 | 591 | 22.1 | 449 | 21.7 |
| Louisiana | 9,609 | 3.8 | 503 | 1.9 | 620 | 2.9 | 245 | 3.7 | 127 | 2.8 | 100 | 3.7 | 78 | 3.8 |
| New Jersey | 21,752 | 8.5 | 2,480 | 9.2 | 1,864 | 8.9 | 492 | 7.5 | 329 | 7.3 | 150 | 5.6 | 140 | 6.8 |
| New Mexico | 6,739 | 2.6 | 556 | 2.1 | 594 | 2.8 | 171 | 2.6 | 110 | 2.5 | 82 | 3.1 | 56 | 2.7 |
| Rural Georgia | 457 | 0.2 | 31 | 0.1 | 31 | 0.1 | 10 | 0.2 | 5 | 0.1 | 6 | 0.2 | 7 | 0.3 |
| San Francisco-Oakland | 22,238 | 8.7 | 1,930 | 7.2 | 1,738 | 8.3 | 497 | 7.6 | 356 | 8.0 | 192 | 7.2 | 125 | 6.0 |
| San Jose-Monterey | 10,534 | 4.1 | 810 | 3.0 | 668 | 3.2 | 193 | 2.9 | 135 | 3.0 | 73 | 2.7 | 37 | 1.8 |
| Seattle-Puget Sound | 23,213 | 9.1 | 2,613 | 9.7 | 2,212 | 10.5 | 726 | 11.1 | 566 | 12.6 | 166 | 6.2 | 157 | 7.6 |
| Utah | 7,423 | 2.9 | 863 | 3.2 | 604 | 2.9 | 187 | 2.9 | 77 | 1.7 | 96 | 3.6 | 91 | 4.4 |
| Race/ethnicity | ||||||||||||||
| Non-Hispanic white | 200,233 | 78.3 | 22,420 | 83.3 | 18,186 | 86.3 | 5,152 | 78.5 | 4,028 | 90.0 | 1960 | 73.3 | 1325 | 63.9 |
| African American | 21,790 | 8.5 | 1,561 | 5.8 | 1,126 | 5.3 | 469 | 7.1 | 159 | 3.6 | 321 | 12.0 | 400 | 19.3 |
| Asian/Pacific Islander | 18,164 | 7.1 | 1,437 | 5.3 | 819 | 3.9 | 599 | 9.1 | 156 | 3.5 | 115 | 4.3 | 128 | 6.2 |
| Hispanic white | 12,445 | 4.9 | 1,282 | 4.8 | 780 | 3.7 | 271 | 4.1 | 103 | 2.3 | 252 | 9.4 | 195 | 9.4 |
| American Indian/Alaska Native | 1,826 | 0.7 | 86 | 0.3 | 70 | 0.3 | 43 | 0.7 | 24 | 0.5 | 9 | 0.3 | 7 | 0.3 |
| Other | 1,260 | 0.5 | 114 | 0.4 | 81 | 0.4 | 27 | 0.4 | 7 | 0.2 | 16 | 0.6 | 17 | 0.8 |
| AJCC stage | ||||||||||||||
| I | 124,108 | 48.5 | 11,894 | 44.2 | 8,398 | 39.9 | 4,311 | 65.7 | 4,080 | 90.5 | 0 | 0.0 | 745 | 36.0 |
| II | 102,332 | 40.0 | 11,621 | 43.2 | 9,016 | 42.8 | 1,962 | 29.9 | 398 | 8.9 | 0 | 0.0 | 1211 | 58.4 |
| III | 20,678 | 8.1 | 2,680 | 10.0 | 2,835 | 13.5 | 205 | 3.1 | 18 | 0.4 | 2129 | 79.6 | 99 | 4.8 |
| IV | 8,600 | 3.4 | 705 | 2.6 | 813 | 3.9 | 83 | 1.3 | 11 | 0.2 | 544 | 20.4 | 17 | 0.8 |
| Grade | ||||||||||||||
| 1 | 43,704 | 17.1 | 5,235 | 19.5 | 5,658 | 26.9 | 3,850 | 58.7 | 3,971 | 88.7 | 43 | 1.6 | 22 | 1.1 |
| 2 | 105,856 | 41.4 | 14,624 | 54.4 | 11,610 | 55.1 | 2,294 | 35.0 | 456 | 10.2 | 579 | 21.7 | 152 | 7.3 |
| 3 | 101,309 | 39.6 | 6,649 | 24.7 | 3,443 | 16.7 | 385 | 5.9 | 49 | 1.1 | 1894 | 70.9 | 1721 | 83.1 |
| 4 | 4,849 | 1.9 | 392 | 1.5 | 351 | 16.3 | 32 | 0.5 | 1 | 0.0 | 157 | 5.9 | 177 | 8.5 |
| Tumor size, cm | ||||||||||||||
| <2.0 | 144,431 | 56.5 | 14,523 | 54.0 | 9,430 | 44.8 | 4,127 | 62.9 | 4,232 | 94.5 | 50 | 1.9 | 783 | 37.8 |
| 2.0–4.9 | 90,069 | 35.2 | 9,676 | 36.0 | 8,018 | 38.1 | 2,012 | 30.7 | 211 | 4.7 | 203 | 7.6 | 1158 | 55.9 |
| 5.0+ | 18,116 | 7.1 | 2,397 | 8.9 | 3,282 | 15.6 | 390 | 5.9 | 27 | 0.6 | 2248 | 84.1 | 120 | 5.8 |
| Missing | 3,102 | 1.2 | 304 | 1.1 | 332 | 1.6 | 32 | 0.5 | 7 | 0.2 | 172 | 6.4 | 11 | 0.5 |
| Nodal status | ||||||||||||||
| Negative | 163,976 | 64.1 | 16,003 | 59.5 | 12,737 | 60.5 | 5,785 | 88.2 | 4,184 | 93.5 | 310 | 11.6 | 1459 | 70.4 |
| Positive | 87,936 | 34.4 | 10,613 | 39.5 | 7,996 | 38.0 | 706 | 10.8 | 283 | 6.3 | 2002 | 74.9 | 604 | 29.2 |
| Missing | 3,806 | 1.5 | 284 | 1.1 | 329 | 1.6 | 70 | 1.1 | 10 | 0.2 | 361 | 13.5 | 9 | 0.4 |
| ER/PR status | ||||||||||||||
| ER+/PR+ | 160,943 | 62.9 | 21,258 | 79.0 | 16,206 | 76.9 | 5,509 | 84.0 | 3,656 | 81.7 | 969 | 36.3 | 226 | 10.9 |
| ER+/PR− | 31,070 | 12.2 | 3,616 | 13.4 | 3,605 | 17.1 | 833 | 12.7 | 669 | 14.9 | 357 | 13.4 | 134 | 6.5 |
| ER−/PR+ | 5,374 | 2.1 | 316 | 1.2 | 279 | 1.3 | 33 | 0.5 | 58 | 1.3 | 126 | 4.7 | 75 | 3.6 |
| ER−/PR− | 58,331 | 22.8 | 1,710 | 6.4 | 972 | 4.6 | 186 | 2.8 | 94 | 2.1 | 1221 | 45.7 | 1637 | 79.0 |
| Surgical treatment | ||||||||||||||
| None | 6,156 | 2.4 | 411 | 1.5 | 523 | 2.5 | 97 | 1.5 | 25 | 0.6 | 420 | 15.7 | 10 | 0.5 |
| Breast conserving surgery | 145,949 | 57.1 | 13,723 | 51.0 | 9,636 | 48.5 | 4,270 | 65.1 | 3,690 | 82.4 | 190 | 7.1 | 1331 | 64.2 |
| Total mastectomy | 103,613 | 40.5 | 12,766 | 47.5 | 10,903 | 51.8 | 2,194 | 33.4 | 762 | 17.0 | 2063 | 77.2 | 731 | 35.3 |
| Radiation treatment | ||||||||||||||
| None | 118,659 | 46.4 | 13,065 | 48.6 | 10,524 | 50.0 | 3,082 | 47.0 | 1,600 | 35.7 | 1177 | 44.0 | 894 | 43.1 |
| Treated with radiation | 137,059 | 53.6 | 13,835 | 51.4 | 10,538 | 50.0 | 3,479 | 53.0 | 2,877 | 64.3 | 1496 | 56.0 | 1178 | 56.9 |
| % of population in county living below 200% of the federal poverty level in the year 2,000 quartiles | ||||||||||||||
| ≥36.31% | 57,646 | 22.5 | 7,139 | 26.5 | 4,384 | 20.8 | 1,673 | 25.5 | 1,100 | 24.6 | 964 | 36.1 | 640 | 30.9 |
| 26.96–36.30% | 61,122 | 23.9 | 6,068 | 22.6 | 5,059 | 24.0 | 1,535 | 23.4 | 996 | 22.2 | 572 | 21.4 | 505 | 24.4 |
| 19.61–26.95% | 67,108 | 26.2 | 6,454 | 24.0 | 5,570 | 26.4 | 1,776 | 27.1 | 1,064 | 23.8 | 619 | 23.2 | 454 | 21.9 |
| ≤19.60% | 69,842 | 27.3 | 7,239 | 26.9 | 6,049 | 28.7 | 1,577 | 24.0 | 1,317 | 29.4 | 518 | 19.4 | 473 | 22.8 |