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Representative CDK2 immunohistochemistry (a–d) of E2-induced mammary premalignant lesions and mammary tumors (MTs). Intense CDK2 positive stained cells were present in E2-induced (a) focal dysplasia, (b) comedo/cribiform ductal carcinoma in situ, and in MT at low (c, ×20) and high magnification (d, ×40).
