Box plots (showing median, 25th and 75th percentiles, and an outlier as a closed circle) of age at the first diagnosis of pheochromocytoma (a), age at diagnosis of malignant disease (b), interval between the diagnosis of pheochromocytoma or paraganglioma to the detection of malignant disease (c) and urine norepinephrine level in the patients who were treated with CVD chemotherapy. CR/PR complete or partial response, NC no change, PD progressive disease. *P < 0.05 vs. PD