Table 2.
Individual characteristics of imaging, extension of the disease, modality of therapy, follow-up, and mutational analysis of CTNNB1 in patients with adamantinomatous craniopharyngioma
| Patient | CT or MRI | Tumor size (cm) | Extension of disease | Treatment | Tumor characteristics | CNS involvement | Follow-up (years, months) | Nucleotide change | Effect of mutation |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MRI | 6.0 | PS | TC/PR | Calcification, solid–cystic | Invasion 3rd ventricle, hydrocephaly | 1 month | TCT → TTT (c.98C>T) | p.Ser33Phe |
| 2 | MRI | 3.1 | PS | TC/PR | Calcification, solid–cystic | Hypothalamic and OQ compression, invasion 3rd ventricle | 2 years | ACC → GCC (c.121A>G) | p.Thr41Ala |
| 3 | MRI | 4.7 | PS | TC/PR | Calcification, cystic | None | 1 year and 7 months | ACC → ATC (c.121C>T) | p.Thr41Ile |
| 4 | MRI | 4.4 | SS | TSS/TR | Calcification, solid | ON/OQ compression, Hydrocephaly | 1 year | No | |
| 5 | MRI | 6.2 | PS | TC/PR | Calcification, solid | None | 1 year | TCT → TGT (c.98C>G) | p.Ser33Cys |
| 6 | MRI | 6.5 | SS | TC+RTX/TR | Solid–cystic | 3rd cranial nerve palsy | 1 year and 3 months | GAC →AAC (c.94G>C) | Asp32Phe |
| 7 | MRI | 5.0 | PS | TC+RTX/PR | Calcification, solid–cystic | Invasion 3rd ventricle | 1 year and 4 months | No | |
| 8 | MRI | 2.5 | PS | TC/TR | Solid | OQ compression, invasion 3rd ventricle | 4 years | TCT → TGT (c.110C>G) | p.Ser37Cys |
| 9 | MRI | 1.5 | PS | TSS/TR | Calcification, solid–cystic | Hypothalamic and OQ compression, hemorrhage | 9 months | TCT → TGT (c.110C>G) | p.Ser37Cys |
| 10 | MRI | 6.5 | SS | TC/PR | Calcification, solid | OQ compression | 3 years | No | |
| 11 | MRI | 4.0 | SS | TC/TR | Calcification, solid–cystic | Hypothalamic and OQ compression | 7 years | No | |
| 12 | MRI | 4.2 | PS | TSS/TR | Calcification, solid–cystic | Hypothalamic and OQ compression, hemorrhage | 1 year | No | |
| 13 | MRI | 2.5 | SS | TSS/TR | Calcification, solid–cystic | Hydrocephaly | 7 months | No | |
| 14 | MRI | 4.8 | PS | TC/TR | Calcification, solid–cystic | Hypothalamic and OQ compression | 1 year and 10 months | GGA → GAA (c.101G>A) | p.Gly34Glu |
| 15 | CT | 3.2 | SS | TC+RTX/PR | Calcification, solid | None | 16 years | No | |
| 16 | MRI | 2.5 | SS | TC/PR | Calcification, solid–cystic | None | 2 years and 6 months | No |
CT computerized tomography, SS suprasellar extension, PS parasellar extension, CNS central nervous system, OQ optic chiasm, ON optic nerve, TC transcranial surgery, TSS transsphenoidal surgery, RTX radiotherapy, TR total surgical removal, PR partial surgical removal