Table 4.

miRNA expression in craniopharyngiomas compared to normal pituitary tissues

miRNA	Mean ΔCt normal	Mean ΔCt tumor	Normal mean 2−ΔΔCt·median range	Tumor mean 2−ΔΔCt·median range	Fold tumor/normal
miR-150	−1.7 ± 1.9	−4.5 ± 2.2	1.3 ± 1.2; 1.0 (0.02–4.6)	12.6 ±17.3; 8.1 (0.3–66.5)	1.7 (p = 0.01)
miR-16-1	3.4 ± 1.5	4.2 ± 1.9	1.5 ± 1.3; 1.0 (0.1–4.8)	1.5 ± 1.4; 0.7 (0.04–4.4)	ns
miR-21	−6.4 ± 1.4	−6.9 ± 1.7	1.4 ±1.4; 1.0 (0.2–4.7)	2.8 ±4.9; 1.7 (0.2–20.7)	ns
miR-23a	−1.3 ± 0.6	−1.6 ± 1.6	1.0 ± 0.4; 1.0 (0.5–1.8)	1.9 ± 2.1; 1.5 (0.2–8.1)	ns
miR-141	−4.5 ± 1.1	−1.3 ± 2.8	1.4 ± 0.8; 1.0 (0.2–2.7)	0.3 ± 0.43; 0.1 (0–1.5)	−7.5 (p < 0.0001)
let7a	−8.2 ± 1.8	−4.8 ± 1.9	1.7 ± 1.7; 1 (0.5–6.7)	0.2 ± 0.3; 0.1 (0.01–0.9)	−7.4 (p < 0.001)
miR-16	−9.7 ± 1.0	−6.7 ± 1.9	1.2 ±0.9; 1.0 (0.2–4.2)	0.2 ±0.2; 0.1 (0–0.9)	−7.2 (p < 0.0001)
miR-449	4.3 ± 0.6	5.9 ± 2.6	1.0 ±0.4; 1.0 (0.4–1.8)	1.8 ±4.3; 0.2 (0.03–16.3)	−6.6 (p = 0.007)
miR-145	−1.1 ± 1.1	1.6 ± 2.7	1.2 ± 1.3; 1.0 (0.2–5.5)	0.5 ± 0.8; 0.19 (0–3.3)	−5.4 (p = 0.002)
miR-143	−1.3 ± 0.8	0.4 ± 2.0	1.3 ± 0.7; 1.0 (0.4–2.9)	1.0 ± 1.8; 0.26 (0.05–7.4)	−3.8 (p = 0.01)
miR-23b	−5.7 ± 0.6	−4.6 ± 1.5	1.0 ± 0.4; 1.0 (0.4–1.6)	0.8 ± 0.9; 0.31 (0.1–3.2)	−3.2 (p = 0.02)
miR-15a	−1.4 ± 0.8	0.1 ± 1.5	1.0 ± 0.5; 1.0 (0.3–2.1)	0.6 ± 0.6; 0.39 (0.04–2.1)	−2.5 (p = 0.009
miR24-2	2.6 ± 0.6	4.2 ± 2.6	1.2 ± 0.5; 1.0 (0.4–2.2)	0.8 ± 1.1; 0.4 (0–4.3)	−2.5 (p = 0.01)

ns not significant