Table 1.
Summary of studies evaluating the sensitivity and specificity of FDG PET in the detection of malignant adrenal lesions and including cases of ACC
| Patients (n) | Verification (n), biopsy/histology | Malignant (n) | ACC (n) | Method | Sensitivity | Specificity | |
|---|---|---|---|---|---|---|---|
| Maurea et al., 2001 [53] | 26 | 26 | 13 | 6 | Visuala | 100% | 100% |
| Zettinig et al., 2004 [82] | 16 | 15 | 3 | 1 | Visuala | 100% | 100% |
| Tenenbaum et al., 2004 [65] | 13 | 13 | 4 | 3 | Visuala | 100% | 100% |
| Metser et al., 2006 [54] | 150 | 6 | 68 | 2 | SUVmax (3.1) | 98.5% | 92% |
| Han et al., 2007 [35] | 105 | 22 | 64 | 3 | SUVmax | NA | NA |
| Caoili et al., 2007 [18] | 59 | 4 | 12 | 1 | SUVmax and SUR | NA | NA |
| Tessonier et al., 2008 [67] | 37 | 29 | 12 | 3 | Visuala | 100% | 86% |
| SUVmax (3.28) | 91.7% | 71.4% | |||||
| SUR (1.8) | 100% | 100% | |||||
| Groussin et al., 2009 [32] | 65 | 65 | 22 | 22 | SUVmax (3.4) | 100% | 70% |
| SUR (1.45) | 100% | 88% | |||||
| Ansquer et al., 2010 [3] | 78 | 72 | 27 | 10 | Visuala | 89% | 76% |
| SUVmax (3.3) | 93% | 78% |
NA not available, SUR tumor/liver SUVmax ratio
aConsidering malignancy in case FDG uptake higher than blood pool or normal liver parenchyma