Table 2.
HbA1c and serum levels of insulin, IGF-1, IGFBP-3, IGFBP-2, and adiponectin and NEFA in db/db mice treated with increasing insulin doses (glargine or NPH) or saline (control)
| Parameter | Glargine (n = 6) | NPH (n = 6) | Saline (n = 4) | |||
|---|---|---|---|---|---|---|
| Day 5 | Day 126 | Day 5 | Day 126 | Day 5 | Day 126 | |
| HbA1c (%) | 2.66 ± 0.14 | 4.37 ± 0.29 | 2.75 ± 0.21 | 3.83 ± 0.19 | 2.80 ± 0.26 | 7.95 ± 0.68b |
| Insulin (ng/ml) | 24.7 ± 7.65 | 1181.2 ± 261.67 | 17.5 ± 7.01 | 453.4 ± 202.79 | 25.5 ± 5.28 | 3.1 ± 1.28b |
| IGF-1 (ng/ml) | 245.83 ± 28.20 | 211.00 ± 18.93a | 191.00 ± 14.33 | 147.17 ± 13.73a | 213.50 ± 29.45 | 188.75 ± 40.86 |
| IGFBP-3 (ng/ml) | 434.76 ± 64.33 | 265.61 ± 21.00a | 334.96 ± 26.52 | 185.66 ± 22.38a | 358.44 ± 49.60 | 331.77 ± 66.96b |
| Molar ratio IGF-1/IGFBP-3 | 2.20 ± 0.32 | 2.97 ± 0.23 | 2.13 ± 0.13 | 3.02 ± 0.22 | 2.21 ± 0.06 | 2.06 ± 0.18b |
| IGFBP-2 (ng/ml) | ND | 34.77 ± 3.94a | ND | 45.74 ± 1.76a | ND | 64.33 ± 15.37b |
| Adiponectin (μg/ml) | 55.02 ± 8.46 | 40.25 ± 5.61 | 50.87 ± 3.70 | 42.09 ± 5.07 | 30.41 ± 7.38b | 47.24 ± 17.44 |
| NEFA (mmol/l) | ND | 2.70 ± 0.18 | ND | 2.59 ± 0.22 | ND | 2.87 ± 0.28 |
aSignificant differences (p < 0.05) between groups treated with NPH insulin or insulin glargine
bSignificant difference (p < 0.05) between saline-treated control group and insulin-treated animals