Fig. 3.

Locational relationship between estrogen-responsive genes and ERBS. a An ERBS was located in the upstream of MLL5. Lower panel shows the result of RNA-seq, indicating that MLL5 is up-regulated by E₂. b An ERBS was located in the second exon of the FAM84B. Lower panel shows the result of RNA-seq, indicating that FAM84B is up-regulated by E₂. c An ERBS was located in the first intron of insulin-like growth factor binding protein 4 (IGFBP4). Lower panel shows the result of RNA-seq, indicating that IGFBP4 is up-regulated by E₂. d ERBSs were located in the upstream, fourth intron, and downstream of cyclin D1 (CCND1). Lower panel shows the result of RNA-seq, indicating that CCND1 is up-regulated by E₂