Fig. 5.

Treatment with soy protein isolate with isoflavones did not affect mammary tumor incidence or latency or uterine weight in ovariectomized Neu mice. a The incidence in mammary tumors in intact (n = 81 control, n = 78 soy) and ovariectomized (OVX; n = 33 control, n = 41 soy) mice at maximum age of 13.5 months is shown. In OVX mice, the incidence is similar for the control and soy groups. A significantly lower incidence was detected in OVX vs. intact Neu mice. ***p < 0.0001, Fisher’s exact test for intact vs. OVX mice (same treatment). b Mammary tumor latency was not different between the intact and OVX groups for either treatment group up to the maximum age of 13.5 months (p > 0.05, two-way ANOVA; n = 73 intact/control, n = 66 intact/soy, n = 7 OVX/control, n = 9 OVX/soy). c Uterine wet weight normalized to body weight was similar for OVX Neu mice in the control and soy groups (p > 0.05, Mann–Whitney). Body weight was also not significant (data not shown)