TABLE 4.

Multivariable adjusted ^a hazard ratio (HR) and 95% confidence interval (CI) estimates for CSS in patients with CRC adenocarcinoma, 2000–2019.

Characteristic	Deaths	HR (95% CI)	p value
Race/ethnicity
White	68,226	1.00 (Ref.)
Black	14,833	1.17 (1.14–1.19)	<0.001
Hispanic	10,934	0.99 (0.98–1.02)	0.934
American Indian	795	1.10 (1.03–1.18)	0.007
API	7473	0.97 (0.94–0.99)	<0.001
East Asian	3384	0.96 (0.93–0.99)	0.018
Southeast Asian	2633	1.01 (0.97–1.05)	0.730
South Asian	345	0.81 (0.72–0.90)	<0.001
Pacific Islander	623	1.17 (1.08–1.27)	<0.001
Sex
Female	42,483	1.00 (Ref.)
Male	59,853	1.12 (1.11–1.14)	<0.001
Age at diagnosis
50–54	14,585	1.00 (Ref.)
55–59	18,323	1.08 (1.06–1.11)	<0.001
60–64	21,282	1.17 (1.14–1.19)	<0.001
65–69	23,340	1.24 (1.22–1.27)	<0.001
70–74	24,806	1.45 (1.42–1.48)	<0.001
Marital status
Married	56,242	1.00 (Ref.)
Divorced/separated	13,692	1.22 (1.19–1.24)	<0.001
Single	17,531	1.28 (1.26–1.30)	<0.001
Unmarried/domestic partner	146	1.22 (1.04–1.44)	0.015
Widowed	9693	1.23 (1.20–1.26)	<0.001
Unknown	5032	1.03 (1.00–1.06)	0.031
Median income
≥$75,000	28,287	1.00 (Ref.)
$65,000–$74,999	22,459	1.09 (1.07–1.11)	<0.001
$55,000–$64,999	25,469	1.12 (1.11–1.15)	<0.001
<$55,000	26,110	1.21 (1.18–1.23)	<0.001
Unknown	11	0.88 (0.47–1.63)	0.684
Subsite
Distal colon	25,646	1.00 (Ref.)
Proximal colon	38,643	1.20 (1.18–1.22)	<0.001
Rectum	33,847	1.09 (1.07–1.11)	<0.001
Colon, NOS	4200	1.35 (1.31–1.67)	<0.001
Surgery
Yes	75,276	1.00 (Ref.)
No/unknown	27,060	2.43 (2.39–2.47)	<0.001
Diagnosis year
2000–2004	31,872	1.00 (Ref.)
2005–2009	28,919	0.85 (0.84–0.86)	<0.001
2010–2014	26,649	0.77 (0.76–0.79)	<0.001
2015–2019	14,896	0.67 (0.66–0.68)	<0.001

Note: Patients listed as “other Asian” were included in the aggregate API group (deaths = 488).

Abbreviations: API, Asian/Pacific Islander (aggregate of all subgroups); CI, confidence interval; HR, hazards ratio.

^a Stratified by stage at diagnosis; adjusted for all variables in the table.