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Summary of full-length WRN high-throughput screening campaign using a catch-all multiplexed assay to measure ATPase, helicase, and exonuclease activities from the same well. (A) Helicase (top) and exonuclease (bottom) readout Z′-factors across all plates from the primary screen. (B) Screening funnel utilized to filter primary hits and determine hit selectivity for FL-WRN versus the individual helicase and exonuclease domains.
