Table 4. Kinetic Parameters of 2-Sulfonyl/Sulfonamide Pyrimidines.
| compound | kinact (s–1) | KI (nM) | kinactKI–1 (M–1 s–1) |
|---|---|---|---|
| H3B-859 | 5.6 × 10–4 | 3090 | 180 |
| H3B-219 | 3.5 × 10–4 | 630 | 562 |
| H3B-960 | 4.5 × 10–4 | 32 | 14,000 |
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