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Hypothetical comparison of parameters of probiotic release in vivo versus in vitro conditions.
| Parameter | In vivo | In vitro |
|---|---|---|
| Time | 5 min on average | 15 min |
| Release from lozenge | Slowly by dissolving | Completely crushed tablet before adding to liquid |
| Volume (saliva/PBS) | 1–5 mL | 10 mL (mostly dissolved, except for large lozenges) |
| Salivary washout | Yes | No |
| Mixing with saliva/liquid | Mastication by tongue and teeth | Inverting, incubation at 300 rpm and 15 s vortex |
